diff --git a/src/duckdb_py/arrow/pyarrow_filter_pushdown.cpp b/src/duckdb_py/arrow/pyarrow_filter_pushdown.cpp
index 66a6e3fa..af05789a 100644
--- a/src/duckdb_py/arrow/pyarrow_filter_pushdown.cpp
+++ b/src/duckdb_py/arrow/pyarrow_filter_pushdown.cpp
@@ -160,6 +160,15 @@ py::object GetScalar(Value &constant, const string &timezone_config, const Arrow
 	}
 }
 
+static py::list TransformInList(const InFilter &in) {
+	py::list res;
+	ClientProperties default_properties;
+	for (auto &val : in.values) {
+		res.append(PythonObject::FromValue(val, val.type(), default_properties));
+	}
+	return res;
+}
+
 py::object TransformFilterRecursive(TableFilter &filter, vector<string> column_ref, const string &timezone_config,
                                     const ArrowType &type) {
 	auto &import_cache = *DuckDBPyConnection::ImportCache();
@@ -282,17 +291,9 @@ py::object TransformFilterRecursive(TableFilter &filter, vector<string> column_r
 	}
 	case TableFilterType::IN_FILTER: {
 		auto &in_filter = filter.Cast<InFilter>();
-		ConjunctionOrFilter or_filter;
-		value_set_t unique_values;
-		for (const auto &value : in_filter.values) {
-			if (unique_values.find(value) == unique_values.end()) {
-				unique_values.insert(value);
-			}
-		}
-		for (const auto &value : unique_values) {
-			or_filter.child_filters.push_back(make_uniq<ConstantFilter>(ExpressionType::COMPARE_EQUAL, value));
-		}
-		return TransformFilterRecursive(or_filter, column_ref, timezone_config, type);
+		auto constant_field = field(py::tuple(py::cast(column_ref)));
+		auto in_list = TransformInList(in_filter);
+		return constant_field.attr("isin")(std::move(in_list));
 	}
 	case TableFilterType::DYNAMIC_FILTER: {
 		//! Ignore dynamic filters for now, not necessary for correctness
diff --git a/tests/fast/arrow/test_filter_pushdown.py b/tests/fast/arrow/test_filter_pushdown.py
index 7938585a..d2eea92e 100644
--- a/tests/fast/arrow/test_filter_pushdown.py
+++ b/tests/fast/arrow/test_filter_pushdown.py
@@ -921,6 +921,33 @@ def test_in_filter_pushdown(self, duckdb_cursor):
         duckdb_conn.register("duck_probe_arrow", duck_probe_arrow)
         assert duckdb_conn.execute("SELECT * from duck_probe_arrow where a = any([1,999])").fetchall() == [(1,), (999,)]
 
+    @pytest.mark.timeout(10)
+    def test_in_filter_pushdown_large_list(self, duckdb_cursor):
+        """Large IN lists must not hang. Regression test for https://github.com/duckdb/duckdb-python/issues/52."""
+        arrow_table = pa.table({"a": pa.array(range(5000))})
+        in_list = ", ".join(str(i) for i in range(0, 5000, 2))
+        result = duckdb.sql(f"SELECT count(*) FROM arrow_table WHERE a IN ({in_list})").fetchone()
+        assert result == (2500,)
+
+    def test_in_filter_pushdown_with_nulls(self, duckdb_cursor):
+        arrow_table = pa.table({"a": pa.array([1, 2, None, 4, None, 6])})
+        # IN list without NULL: null rows should not match
+        result = duckdb.sql("SELECT a FROM arrow_table WHERE a IN (1, 4) ORDER BY a").fetchall()
+        assert result == [(1,), (4,)]
+        # IN list with NULL: null rows still should not match (SQL semantics)
+        result = duckdb.sql("SELECT a FROM arrow_table WHERE a IN (1, 4, NULL) ORDER BY a").fetchall()
+        assert result == [(1,), (4,)]
+
+    def test_in_filter_pushdown_varchar(self, duckdb_cursor):
+        arrow_table = pa.table({"s": pa.array(["alice", "bob", "charlie", "dave", None])})
+        result = duckdb.sql("SELECT s FROM arrow_table WHERE s IN ('bob', 'dave') ORDER BY s").fetchall()
+        assert result == [("bob",), ("dave",)]
+
+    def test_in_filter_pushdown_float(self, duckdb_cursor):
+        arrow_table = pa.table({"f": pa.array([1.0, 2.5, 3.75, 4.0, None], type=pa.float64())})
+        result = duckdb.sql("SELECT f FROM arrow_table WHERE f IN (2.5, 4.0) ORDER BY f").fetchall()
+        assert result == [(2.5,), (4.0,)]
+
     def test_pushdown_of_optional_filter(self, duckdb_cursor):
         cardinality_table = pa.Table.from_pydict(
             {